Protein Details: Aquaporin Z 2

Protein ID

ICDB_Pro_1381

Protein Name

Aquaporin Z 2

Gene Name

aqpZ2; RA0329; SMa0627

Organism

Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

Length

232 amino acids

AlphaFoldDB

AF-Q92ZW9-F1-model_v4.pdb

Function

Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.

Sequence

MFKKLCAEFLGTCWLVLGGCGSAVLASAFPQVGIGLLGVSFAFGLTVLTMAYTVGGISGGHFNPAVSLGLAVAGRVPAASLVSYVIAQVAGAIIAAAVLYVIATGKADFQLGSFAANGYGEHSPGGYSLTAALVTEVVMTFFFLIIILGSTHRRVPAGFAPIAIGLALTLIHLVSIPVTNTSVNPARSTGQALFVGGWALSQLWLFWIAPLFGAAIAGIVWKSVGEEFRPVD

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 20: "Involved in tetramerization or stability of the tetramer"; SITE 43: "Selectivity filter"; SITE 172: "Selectivity filter"; SITE 181: "Selectivity filter"; SITE 187: "Selectivity filter"

Disease

Location

DOI ID

10.1073/pnas.161294798; 10.1126/science.1060966

RefSeq

NP_435575.1; WP_010967322.1